Cystic Fibrosis Patient Info
Short summary:
Cystic brosis (CF) is one of the most common inherited diseases in US Caucasians. It is caused by a failure of a protein that maintains the chloride (salt) balance in the body. This causes respiratory ...
Long summary:
Cystic Fibrosis Patient Info Cystic Fi bro sis This publication and the information contained within are not intended to serve as a disclosure or informed consent nor to comply with any ap pli ca ble laws or regulations. Your physician will provide the information about this test and any informed consent form necessary or required. ©2002 Laboratory Corporation of America ® Holdings All Rights Reserved L935-1102-2 6041293201 What is Cystic Fibrosis? Cystic brosis (CF) is one of the most common inherited diseases in US Caucasians. 1 It is caused by a failure of a protein that maintains the chloride (salt) balance in the body. This causes respiratory problems (breathing problems and lung infections), digestive problems (di culty in absorbing some types of foods), and infertility. 1 CF does not cause mental retardation or birth defects. 1 The symptoms of CF can be highly variable; they can be mild in some people and cause a life-threatening illness in others. With extensive treatment, the average person with CF lives into the third decade. 1 Who is at risk for cystic brosis? Cystic brosis is most common in Caucasians, but is found in all ethnic groups. 1 Even if an individual has no family history of CF or a child with CF, it is possible to be a CF carrier. Approximately 1 in 2500 Caucasians is born with the disease. 2 The carrier frequency of several ethnic groups is shown in Table 1. The chance of being a carrier is higher for those who have a family history of CF. Table 1. Carrier frequency of CF Ethnicity Carrier Frequency Caucasian (non-Hispanic) 1/25 2 Ashkenazi Jewish 1/25 2 Hispanic American 1/46 2 African American 1/65 2 References 1. Brown T, Langfelder Schwind E. Update and review: Cystic brosis. J Genet Couns. 1999; 8(3):137-162. 2. Richards CS, Bradley LA, Amos J, et al. Standards and Guidelines for CFTR Mutation Testing. Genet Med. 2002; 4(5):379-391. 3. American College of Obstetricians and Gynecologists, American College of Medical Genetics. Preconception and Prenatal Carrier Screening for Cystic Fibrosis: Clinical and Laboratory Guidelines. 5. Based on internal Bayesian calculation on le. What causes CF? Cystic brosis is an inherited genetic condition. 1 It is inherited in a recessive manner. That means that both parents must be carriers to have an a ected child. Being a carrier does not a ect a persons health. Only when both parents are carriers of CF can the disease occur in their children. When both ...
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